Forty Years of mRNA Splicing: From Discovery to Therapeutics
October 22 - 25, 2017
Mila Pollock, Cold Spring Harbor Laboratory
Phil Sharp, Massachusetts Institute of Technology
Joan Steitz, Yale University/HHMI
The meeting will be held in Grace Auditorium at Cold Spring Harbor commencing 1:45 pm on Sunday, October 22, and finish in the late afternoon on Tuesday, with departures the following morning, October 25, after breakfast.
History and Overview
Biology of Spliceosome
Introns, Exons and Alternative splicing
Diseases of mRNA splicing
Therapeutic approaches to mRNA Splicing diseases
For these unique meetings, we invite speakers who made many of the seminal discoveries that began the field, as well as those who are working on the topic now. We also invite historians of science who have examined the topic, setting it in its scientific and societal context. Like the previous meetings in the series, this meeting will provide an excellent opportunity to look in-depth at a topic and share the stories that are often missing from academic accounts.
We anticipate the meeting will interest a broad range of individuals, including scientists, clinicians, historians, activists, and science journalists.
For more information and registration:
The Human Genome Project (HGP) was a 13-year initiative to sequence the billions of individual bases of human DNA. Despite the landmark nature of the project, there was never any effort to preserve, collect or organize the documentary record of scientists’ work in six countries: this historical documentation lay scattered in archives and other collections in the United States, United Kingdom, France, Germany, Japan, and China.
In 2009, Cold Spring Harbor Laboratory began working with The Wellcome Trust to change this. The International Catalog of the History of the Human Genome Project seeks to fill a large gap for historians and other scholars researching the HGP. The project will create a catalog of the original materials that came out of sequencing the human genome: correspondence, lab notes, photographs, papers, grant applications, oral history interviews, and other files.
For the first time, all the relevant materials documenting the history of the HGP will be identified, organized, and catalogued for the public. The website for the International Catalog of the History of the Human Genome Project is available at genomelegacy.org.
Ballouz & Gillis Genome Med 2017
Functional convergence trend calculation
Li et al eLife 2017
Dynamic expression of lncRNA Ephemeron during exit from naïve pluripotency
Lu et al Nat Neurosci 2017
Optogenetic activation of L2 ChCs in PL inhibits PL firing, including BLAPC firing, in freely behaving mice
Romero-Hernandez & Furukawa Mol Pharmacol 2017
Ligands and domain organization of NMDA receptors
Wu & Tollkuhn Mol Pharmacol 2017
Neonatal deletion of Esr1 in Vglut2+ and Vgat+ neurons
The NIH has announcedthat it will now allow Investigators to cite their interim research products (Preprints, software etc) in Progress Reports, Grant Applications, and Proposals.
The NIH recommends that Investigators use pre-print repositories that are robust and allow the pre-prints to be easily findable, accessible, interoperable and reusable.
A good example of such a repository is biorxiv.org
For more information the NIH guidance can be found here
Reporting Preprints and Other Interim Research Products
A new demand-driven ebook platform is available from the CSHL Library! ProQuest EBook Central provides CSHL researchers and staff an easy way to discover and read a vast collection of scientific and technical books from leading publishers. You are able to easy discover books of interest and can read the full text of any book for 5 minutes. If you decide that the book is worthwhile, simple request the book directly on the website, and your reqest will be processed by a CSHL Librarian.
For details on using the EBook Central, we have a Ebook Central LibGuide.
A major undertaking by the CSHL Library & Archives, the "The Human Genome Project: An Annotated & Interactive Scholarly Guide to the Project in the United States" is now available as an online guide and a downloadable E-Book. The editor is Kevin Davies.
Understanding your rights as an author and copyright this important for all scientists from graduate students to PI's.